Thursday, Apr 30, 2020

Trends in Cell Biology

A Dynamical Paradigm for Molecular Cell Biology

Bela Novak, John J. Tyson

The driving passion of molecular cell biologists is to understand the molecular mechanisms that control important aspects of cell physiology, but this ambition is often limited by the wealth of molecular details currently known about these mechanisms. Their complexity overwhelms our intuitive notions of how molecular regulatory networks might respond under normal and stressful conditions. To make progress we need a new paradigm for connecting molecular biology to cell physiology. We suggest an approach that uses precise mathematical methods to associate the qualitative features of dynamical systems, as conveyed by ‘bifurcation diagrams’, with ‘signal- response’ curves measured by cell biologists.